Abstract
Background: Inflammation is a vascular or tissue response that occurs as a result of infection, tissue injury or irritation. The review is aimed at describing the functions of Interleukin-8 (IL-8) and its role in tissue injury and inflammation.
Methods: Articles were searched from the internet using the following search words; Inteluekin-8, IL-8 structure and functions, role of IL-8 in tissue injury, inflammation and inflammatory response, IL-8 in hepatic, nervous, cardiac and ki...
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Month: May 2018
Plants- Drug Interactions Against Some Multi-drug Resistant Microorganisms Causing Urogenital Tract Infections in Cameroon
Investigational Medicinal Chemistry and Pharmacology 2018 1(1):4
Abstract
Background: Multi drug resistance is an increasing phenomenon plaguing the use of antibiotics nowadays. This favors the spread of pathogenic microorganisms causing a major public health problem. Antimicrobial compounds from medicinal plants can be used synergistically to enhance the activity of standard drugs when used concurrently. The aim of this work was to evaluate the ability of extracts from Skirakiopsis ellip...
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Polyphenolic extract of Paullinia pinnata leaf exhibits antidiabetic, anthyperlipidaemic and antioxidant activities in alloxan-induced diabetic rats
Abstract
Background: This study evaluated the antidiabetic, antihyperlipidaemic and antioxidant effects of polyphenolic extract of Paullinia pinnata leaf (PEPPL) in alloxan-induced diabetic rats.
Method: Diabetes was induced in Albino rats by intraperitoneal administration of alloxan monohydrate (120 mg/kg body weight (b. w.)). Male and female rats of average weight 150 ± 1.14 g were selected for the study. PEPPL at a dose of 25 and 50 mg/kg b. w. was administered single dose per day to a...
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Cytotoxicity of Lupeol from the Stem Bark of Zanthoxylum gilletii against Multi-factorial Drug Resistant Cancer Cell Lines
Investigational Medicinal Chemistry and Pharmacology 2018 1(1):10.
Abstract
Background: Drug resistance is one of the major hurdles in the treatment of cancer. Rather than single factors, drug resistance is caused by multiple mechanisms making it even more complex. In the present study, the cytotoxicity of six compounds isolated from Zanthoxylum gilletii were screened against drug-sensitive leukemia CCRF-CEM cells. The most cytotoxic compound, lupeol (1) was further tested in a panel of n...
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Hepatoprotective activities of Autranella congolensis and Sapium ellypticum against carbone tetrachloride induced liver injuries in experimental rats.
Abstract
Background: Liver injury remains a serious problem worldwide despite advances in drug research. In the perspective of searching for new natural agents that can prevent such abnormalities this study was designed to evaluate the in vivo anti-oxidative properties of the methanolic extracts of Autranella congolensis and Sapium ellypticum.
Methods: The hepatoprotective properties of the extracts were evaluated on 9 groups of 5 Wistar rats using the CCl4 model. Animals were treated oral...
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Anti-staphylococcal and antibiotic-potentiating activities of seven Cameroonian edible plants against resistant phenotypes
Hermione T. Manekeng1, Armelle T. Mbaveng1*, Gaelle S. Nguenang1, Jackson A. Seukep1, Brice E. N. Wamba1, Paul Nayim1, Ngai R. Yinkfu1, Aimé G. Fankam1 and Victor Kuete1
Investigational Medicinal Chemistry and Pharmacology 2018 1(1):7
Abstract
Background: In this study, we evaluated the anti-staphylococcal and antibiotic-potentiating activities against resistant phenotypes of seven Cameroonian dietary plants: Arachis hypogaea; Cola pachycarpa; Curcuma longa; Lycopersicon esculentum; Ma...
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Antibacterial activity of four Cameroonian medicinal plants against MDR bacteria and study of mode of action
Irene Chinda Kengne1, Jean-De-Dieu Tamokou1*
Abstract
Background: The increasing number of resistant bacteria to commonly used antibiotics makes the search for new active molecules a real challenge. The aim of this study is to evaluate the antibacterial activities of crude extracts and fractions from four Cameroonian medicinal plants against multi-resistant bacteria as well their mechanisms of action.
Methods: The crude extracts were prepared by maceration in methanol. The fractionatio...
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In vitro Evaluation of Antioxidant and Anti-sickling properties of Theobroma Cacao (Sterculiaceae) extracts from East and South regions in Cameroon
Abstract
Background: Sickle cell anaemia (SCA) is a genetic disease associated with increased mortality in Africa. It generates polymerization of haemoglobin, free radicals proliferation and antioxidants deficiencies. SCA management still needs new and safe drugs. The aim of this study is to evaluate the antioxidant and anti-sickling properties of cocoa extracts from two localities of Cameroon.
Methods: T. cacao beans were collected in Bertoua and Mbalmayo They were dried, ground and then...
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