Antidermatophytic activity and adverse side effects of the methanolic extract from leaves of Ageratum conyzoides (Asteraceae)

-Armel-Joseph Agokeng Dongmo; Larissa Chimi Yetendje; Guy Sedar Singor Njateng; Donatien Gatsing; Jules Roger Kuiate.

Abstract Background: The incidence of dermatophytosis has increased in recent years in spite of the availability of antifungal drugs. Faced with all the above, medicinal plants could be an alternative. So, this work aimed at evaluating antidermatophytic activities of some medicinal plants used in Cameroon against dermatophytoses. Methods: An ethnopharmacological survey was carried out by interview of traditional healers in six villages of Bafou locality. Nine plants were selected and meth...

Inhibitory effects of four naturally occurring compounds from Epicoccum nigrum on acetylcholinesterase activity and nitric oxide production in LPS-activated RAW 264.7 cells

-Raduis Melong; Jean Paul Dzoyem; Armelle T. Tsamo; Deccaux G. W. F. Kapche; Bonaventure T. Ngadjui; Lyndy J. McGaw; Jacobus N. Eloff.

Abstract Background: The role of nitric oxide in the pathogenesis and progression of neurodegenerative illnesses is becoming prominent over the years and the inhibition of acetylcholinesterase (AChE) is considered as a promising strategy in the management of such diseases. This study aims to assess the inhibitory potential of (1) beauvericin, (2) para-hydroxybenzaldehyde, (3) indole-3-carboxylic acid and (4) quinizarin isolated from endophytic fungi Epicoccum nigrum on acetylcholinesterase a...

Anti-staphylococcal activity and antibiotic-modulating effect of Olax subscorpioidea, Piper guineense, Scorodophloeus zenkeri, Fagara leprieurii, and Monodora myristica against resistant phenotypes

-Garandi Badawe; Aimé G. Fankam; Paul Nayim; Brice E. N. Wamba; Armelle T. Mbaveng; Victor Kuete

Abstract Background: The development of new drugs from plants seems to be an interesting alternative approach to overcoming microbial resistance. This study aims to investigate the anti-staphylococcal and antibiotic-potentiating activity of methanolic extracts of five Cameroonian dietary plants namely Piper guineense, Fagara leprieurii, Olax subscorpioïdea, Monodora myristica and Scorodophloeus zenkeri against a panel of multidrug resistance (MDR) Staphylococcus aureus clinical isolates. ...

Influence of the harvesting area on the nutritional value, antioxidant and hypoglycemic properties of Spirulina platensis (Gom.) in diabetic rats (type I diabetic)

-Patrick Fogang Dongmo; Boris Gabin Kingue Azantsa; Dieudonné Kuate; Anne Pascale Nouemsi Kengne; Blaise Beblere Jebkalbe; Cerile Ypolyte Woumbo; Phylippe Tekem Nguekouo; Florian Amel Tekou; Christian Adimadji; Julius Enyong Oben

Abstract Background: The present investigation aimed to study the effect of the harvesting area on the nutritional value, antioxidant and antidiabetic properties of Spirulina (Spirulina platensis) from five zones in type 1 diabetic rats. Methods: Spirulina platensis was collected in dried forms from five zones (Lake Bodou, Lake Kolodorum, Lake Lactir, Lake Touffou and the wadi of Rombou) and then subjected to hydroethanolic extraction (50-50). The nutritional value, the antioxidant pote...