Month: February 2019

Cinnamomum zeylanicum, Dichrostachys glomerata and three other plants had anti-staphylococcal and antibiotic-modifying activity against drug-resistant phenotypes

-Garandi Badawe, Aimé G. Fankam, Armelle T. Mbaveng, Brice E. N. Wamba, Paul Nayim, Victor Kuete

Abstract Background: The increase resistance of Staphylococcus aureus clinically, propels the search of novel approaches to treat staphylococcal infections. This study aims to investigate the anti-staphylococcal activity and antibiotic-modulating effects of the methanol extracts of five Cameroonian dietary plants namely Cinnamomum zeylanicum, Fagara xanthoxyloides, Imperata cylindrica,  Dichrostachys glomerata, Pentadiplanara brazzeana against a panel of S. aureus strains. Methods: The pl...
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Protective Mechanisms of Limonoids from Khaya grandifoliola against Cisplatin-Toxicity in L-02 Hepatocytes: Targeting JNK Activation and Nuclear Translocation of Nrf2

-Arnaud Fondjo Kouam, Frédéric Nico Njayou, Fei Yuan, Babayemi Olawale Oladejo, Pierre Mkounga, Fuhang Song, Paul Fewou Moundipa

Abstract Background: Cisplatin is one of the most effective antineoplastic drugs, but it has undesirable side effects such as hepatotoxicity. This study investigated in vitro the protective activity of three limonoids known as 17-epi-methyl-6-hydroxylangolensate, 7-deacetoxy-7-oxogedunin and deacetoxy-7R-hydroxygedunin, isolated from Khaya grandifoliola (Meliaceae) against cisplatin-induced hepatotoxicity and the possible mechanisms involved in this activity. Methods: Normal human liver...
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