Abstract Background: The folkloric use of Plectranthus aegyptiacus (Forssk.) C. Chr. in the Southwest Nigeria includes;pain, sensory diseases, cough and fever. This study investigated the anxiolytic, sedative, anticonvulsant and analgesic activities of the essential oil of P.aegyptiacus in mice. Methods: The oil was extracted by hydro-distillation.5% Tween-80 (0.1 ml/10 g)was used as negative control and different standard drugs were used as positive controls depending on the model.  The ...