Methanol Extracts from Manilkara zapota with Moderate Antibacterial Activity Displayed Strong Antibiotic-Modulating Effects against Multidrug-Resistant Phenotypes

-Franklin C. M. Ngongang; Aimé G. Fankam; Armelle T. Mbaveng; Brice E. N. Wamba; Paul Nayim; Veronique P. Beng; Victor Kuete.

Abstract Background: The emergence and persistence of multidrug-resistant (MDR) bacteria appears today as a serious threat of growing concern to human health. The aim of this present study was to investigate the antibacterial and antibiotic-modulating activity of the methanol extracts of Manilkara zapota (L.) P. Royen (Sapotaceae) against pathogenic strains belonging to Gram-positive bacterium, Staphylococcus aureus, and Gram-negative bacteria. Methods: The antibacterial activity as well ...

Aqueous extracts of Desmodium adscendens (Fabaceae) possess in vitro antioxidant properties and protect hepatocytes from Carbone tetrachloride-induced injury and Hepatitis C Virus infection

-Pascal D.D. Chuisseu; Borris R.T Galani; Nelly C.K. Younang; Arnaud F. Kouam; Brice F.N. Simo; Angèle N. Tchana; Karin Seron; Jean Dubuisson; Gisa Tiegs; Jonas Kouamouo; Paul F. Moundipa.

Abstract Background: Desmodium adscendens (DA) is an herbaceous plant found in Africa and South America and used in traditional medicine against liver-related diseases. In the present study, the aqueous decoctions from DA were tested for its antioxidant and hepato-(protective and curative) properties on CCl4-induced acute injury on primary culture rats’ hepatocytes. We also investigated its inhibitory effects on hepatitis C virus (HCV) using genotype 1b subgenomic replicon systems and cell-c...