Abstract
Background: Cures for infectious diseases are slowly becoming elusive due to resistance mechanisms of disease-causing microbes. As a result, most conventional medicines are now being rendered ineffective, causing increased difficulty in the treatment of infections and an upsurge of fatalities. In the present study, the anti-bacterial and anti-fungal properties of extracts and compounds of Milletia leucantha were investigated.
Methods: The roots of M. leucantha were exhaustively e...
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Month: June 2020
Investigation of the antihyperlipidemic property of Raphia hookeri mesocarp oil in high-lard diet (HLD) fed rats
Abstract
Background: Dyslipidemia is an important risk factor cardiovascular disease. The mesocarp of R. hookeri has been shown to resemble that of palm oil in term oil quality, with a large quantity of linoleic acid (47.3%) followed by palmitic acid (32.3%), oleic acid (13.7%) and alpha-linolenic acid (1.1%). The present investigation aimed to evaluate the antihyperlipidemic property of crude Raphia hookeri mesocarp oil in male Wistar albino rats fed with high-lard diet (HLD).
Methods:...
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Antidepressant potential of butanol fraction of Milicia excelsa (Moraceae) leaf in mice
Abstract
Background: Milicia excelsa is used to treat mental illnesses among the Hausa ethnic group of Northern Nigeria, but there is lack of scientific investigation to validate this ethnomedicinal claim. Hence, this study investigated the antidepressant-like effect of butanol fraction of Milicia excelsa leaves in mice (BFME).
Methods: The antidepressant-like effect of BFME was investigated using forced swim (FST) and tail suspension (TST) tests in mice. The probable neural mec...
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Antibacterial, antioxydant and antidiarrheal properties of Tristemma hirtum P. beauv.
Abstract
Background: The aim of this study was to investigate the antibacterial, radical-scavenging and antidiarrheal properties of Tristemma hirtum.
Methods: The methanol extract of Tristemma hirtum was prepared by successive fractionation in hexane and ethyl acetate solvents. The phytochemical composition of crude extract and fractions was studied using standard methods. Their antimicrobial activities were evaluated against Gram-negative and Gram-positive species of pathogenic bacteria ...
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Table of Contents _ Volume3, issue 1; July 31, 2020
Volume3, issue 1; July 31, 2020
(Available at: https://www.investchempharm.com/volume/volume3/issue-1/)
https://dx.doi.org/10.31183/imcp.2020.v3i1
Research Article
1- Antipsychotic and anticonvulsant effects of crude aqueous leaf extract of Vitex doniana Sweet (Verbenaceae) In mice
Authors: Joshua Oloruntobi Imoru, Idris Ajayi Oyemitan and Atanda Moses Akanmu. Investigational Medicinal Chemistry and Pharmacology 2020 3(1):35. doi: https://dx.doi.org/10.31183/imcp.2020.00034
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Antimicrobial and antioxidant activities of isolated compounds from the root bark of Croton pseudopulchellus (Euphorbiaceae)
Abstract
Background: Despite the significant progress made in microbiology and the control of microorganisms, sporadic incidents of epidemics due to drug resistant microorganisms pose an enormous threat to public health. Hence, search for new antimicrobial is very important to overcome microbial resistance and emerging pathogenic bacteria and fungi. In this study, we designed to describe the isolation, structure elucidation, antimicrobial and antioxidant activities of components from the roo...
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Anti-amnesic effect of ethanol stem bark extract and fractions of Milicia excelsa (Moraceae) in mice
Abstract
Background: Amnesia is associated with normal aging and neuropsychiatric disorders with no known medical cure. Medicinal plants used in traditional medicines to combat neuropsychiatric disorders may be a veritable vehicle towards providing the appropriate drug candidate(s).
Methods: Hence, this study assessed the anti-amnesic potential of Milicia excelsa stem bark upon its widespread use in traditional medicine for treating mental illnesses. The anti-amnesic potentials of ethanol...
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