Abstract Background: The resistance of gastrointestinal worms to synthetic anthelmintics (Levamisole) leads us to highlight the Cameroonian pharmacopoeia. The main objective of the present work is to look for an alternative treatment for haemonchosis, based on active secondary metabolites, from Portulaca oleracea, with less or no side effects and accessible to all. Methods: The Haemonchus contortus cycle test was performed at varying concentrations. Levamisole and PBS were the positive an...