Antibacterial and antibiotic-modulating activities of Rhinella jimi and three other animal extracts against multidrug-resistant Gram-negative phenotypes

-Michel-Gael F. Guefack; Simplice B. Tankeo; Carine M.N. Ngaffo; Idrios N. Bonsou; Paul Nayim; Brice E.N. Wamba; Victor Kuete; Armelle T. Mbaveng.

Abstract Background: The antibiotic resistance of pathogenic bacteria is one of the major health problems worldwide. The development of novel antimicrobial therapies based on natural products that greatly reduce this resistance is urgent. The present study aimed at evaluating the antimicrobial potential of four animal methanol extracts, Gryllus campestris, Testudo hermanni, Cardisoma guanhumi, and Rhinella jimi as well as their synergistic effects with antibiotics against twenty Gram-negativ...

Modes of action of the methanol extract and 3-O-[β-galactopyranosyl-(1→4)-β-D-galactopyranosyl]-oleanolic acid from Acacia polyacantha against multidrug-resistant Gram-negative bacteria

-Flora T. Mambe; Cedric F. Tchinda; Brice E. N. Wamba; Paul Nayim; Fred Ashu; Hermione T. Manekeng; Veronique P. Beng; Victor Kuete.

Abstract Background: Bacterial infections, especially those caused by multidrug-resistant (MDR) Gram-negative bacteria, remain a global health concern. Previous studies have reported the antibacterial activities of the methanol extract of the leaves of Acacia polyacantha Willd. (Fabaceae) (APL) as well as some of its phytoconstituents. In this study, APL and its constituent, 3-O-[β-galactopyranosyl-(1→4)-β-D-galactopyranosyl]-oleanolic acid (GGOA) were evaluated on growth kinetics, bacterial...