Abstract Background: View the rapid spread of multidrug-resistant bacteria worldwide; alternatives to antibiotics are necessary for handling various bacterial infections. This study aimed to investigate the antibacterial activity of eight flavonoids isolated from the leaves methanol extract of Bauhinia thonningii against multi-drug resistant (MDR) bacteria expressing efflux pumps. Methods: The antibacterial activity of the phytochemicals alone and in the presence of phenylalanine-arginine...