Abstract Background: Nephrotoxicity is a common kidney condition affecting many people worldwide, with conventional synthetic drugs not often yielding desirable results. This study, therefore, aimed to assess the protective effect of Solanum macrocarpon on Cisplatin-induced nephrotoxicity in Wistar rats. Methods: Hydroethanolic extract of the leaves of S. macrocarpon was prepared and analyzed for basic phytochemical constituents. Cisplatin (5 mg/kg) was administered to induce nephrotoxici...