Pericopsis laxiflora (Baker) Stem bark extract ameliorates acute Lead-induced hepatotoxicity: Modulation of Oxidative Stress and Inflammatory Pathways

-Frederick Sarfo-Antwi; Christopher Larbie; Benjamin Obukowho Emikpe; Regina Appiah–Opong.

Abstract Background: Heavy metals such as lead are considered a toxicant that can cause multiple organ complications including cancer, liver disease, renal diseases, neurodegenerative diseases, and reproductive diseases. In pursuit of a low-cost and easily accessible antidote, this research examined the role of Pericopsis laxiflora extract in acute lead poisoning in Sprague-Dawley rats. Methods: Liver damage was caused in animal studies by inducing lead acetate (50 mg/kg daily, intraperit...

Botanicals from the flowers of Vernonia calvoana and the leaves of Senna spectabilis showed anti-Klebsiella activity and potentiated the activity of antibiotics against multidrug-resistant phenotypes overexpressing efflux pumps

-Derick J. Assonfack; Eric Cadet; Larissa Mpude; Ancela W. B. Yendze; Valaire Y. Matieta; Jenifer R. N. Kuete; Junior F. Megaptche; Idrios N. Bonsou; Michael F. Kengne; Armelle T. Mbaveng; Victor Kuete.

Abstract Background: The alarming trend of infectious diseases in public health is mainly due to bacterial multidrug resistance, the emergence of which is partly caused by the inappropriate use of antibiotics. Bacteria of the Klebsiella genus have acquired a priority level of resistance to antibiotics, reducing their effectiveness. The aim of this study was to evaluate the anti-Klebsiella activity of methanol extracts of Vernonia calvoana flowers and Senna spectabilis leaves against multidru...