Abstract
Background: Nephrotoxicity is a common kidney condition affecting many people worldwide, with conventional synthetic drugs not often yielding desirable results. This study, therefore, aimed to assess the protective effect of Solanum macrocarpon on Cisplatin-induced nephrotoxicity in Wistar rats.
Methods: Hydroethanolic extract of the leaves of S. macrocarpon was prepared and analyzed for basic phytochemical constituents. Cisplatin (5 mg/kg) was administered to induce nephrotoxici...
More
Research article
Antibacterial and antibiotic-potentiation activities of methanol extracts from Blighia sapida K. D. Koenig (Sapindaceae) against Gram-negative multidrug-resistant bacteria overexpressing efflux pumps
Abstract
Background: The emergence and spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly those overexpressing efflux pumps, make treatment difficult using conventional antibiotics. This study aims to assess the antibacterial activity of methanol extracts (botanicals) from the leaves (BSL) and bark (BSB) of Blighia sapida against a panel of MDR bacteria that overexpress efflux pumps.
Methods: Phytochemical screening of botanicals was carried out using standard qualit...
More
Unveiling the anti-Klebsiella activity of methanol extracts from Hallea ciliata leaves and barks against multidrug-resistant strains overexpressing AcrAB-TolC efflux pumps
Abstract
Background: Infectious diseases are considered one of the most critical threats to public health. The present work aimed to determine the anti-Klebsiella activity of methanol extracts (botanicals) of Hallea ciliata leaves (HCL) and bark (HCB) against multidrug-resistant phenotypes over-expressing ACrAB-TolC efflux pumps.
Methods: The antibacterial activity of botanicals alone and in combination with PAβN and antibiotics, was determined using the broth microdilution method. The ef...
More
Antibacterial activity and antibiotic-potentiating effects of methanol extracts from Ocimum basilicum and Sarcocephalus latifolius against multidrug-resistant Gram-negative bacteria overexpressing efflux pumps
Abstract
Background: The inappropriate use of antibiotics against bacterial infections leads to increased bacterial drug resistance. In the present study, the effectiveness of methanol extracts from the leaves and flowers of Ocimum basilicum and the roots of Sarcocephalus latifolius against multidrug-resistant (MDR) Gram-negative bacteria overexpressing efflux pumps was assessed.
Methods: The antibacterial properties of crude extracts (botanical, with and without phenylalanine arginine β-...
More
Antibacterial activity of Sarcocephalus latifolius and Acacia sieberiana, and the effect of their association with antibiotics against multidrug-resistant Staphylococcus aureus
Abstract
Background: Infectious diseases continue to wreak havoc around the world causing directly or indirectly 17 million deaths per year. The present study was carried out to evaluate the in vitro antibacterial activity of the methanol extracts from the root of Sarcocephalus latifolius and from the leaves of Acacia siberiana, and their ability to potentiate the action of antibiotics against multidrug-resistant (MDR) Staphylococcus aureus.
Methods: The antibacterial assays were performe...
More
Ethnopharmacology and anthelmintic screening of some plants used in traditional medicine in the Far-North of Cameroon
Background: The use of traditional medicinal plants in Cameroon for the treatment of intestinal helminthiasis is a common practice among traditional healers and livestock breeders. However, the use of ethnopharmaceutical products for their anthelmintic activities against Haemonchus contortus has been poorly addressed in the Far-North region of Cameroon, therefore justifying the need to bridge this gap.
Methods: An ethno-pharmacological survey was conducted among livestock breeders and traditi...
More
Chemical constituents of Palisota ambigua (Commelinaceae) with their antibacterial activities
Background: The development and spread of resistance by bacteria to existing antibiotics are becoming more common nowadays. Considering the ethnopharmacological relevance of Palisota ambigua (Commelinaceae), this study was designed to investigate the antibacterial activities of chemical constituents of P. ambigua against two Gram-positive (Staphylococcus aureus ATCC 25923 and Streptococcus pneumoniae ATCC 49619) and two Gram-negative (Escherichia coli ATCC 8739 and Klebsiella pneumoniae 109 (iso...
More
Antibacterial activity of phytochemicals from Bauhinia thonningii significantly increased in the presence of the efflux pump inhibitor, phenylalanine-arginine-β-naphthylamide towards multidrug-resistant phenotypes
Abstract
Background: View the rapid spread of multidrug-resistant bacteria worldwide; alternatives to antibiotics are necessary for handling various bacterial infections. This study aimed to investigate the antibacterial activity of eight flavonoids isolated from the leaves methanol extract of Bauhinia thonningii against multi-drug resistant (MDR) bacteria expressing efflux pumps.
Methods: The antibacterial activity of the phytochemicals alone and in the presence of phenylalanine-arginine...
More
Effect of combination of doxycycline with natural products against planktonic cells, biofilm, and virulence factor of Pseudomonas aeruginosa
Abstract
Background: Pseudomonas aeruginosa is an important environmental, opportunistic, and nosocomial pathogen with a significant threat to public health. Combination therapy has many advantages due to the simultaneous action of two drugs on two separate cellular targets. In the present study, the effect of the combination of doxycycline and natural products against planktonic cells, biofilm, and virulence factors of P. aeruginosa was evaluated.
Methods: To perform this work, minimal i...
More
A moderately active crude methanol extract from the whole plant of Kalanchoe crenata (Andrews) Haw. (Crassulaceae) strongly potentiated the effect of antibiotics against multidrug-resistant Gram-negative bacteria
Abstract
Background: Resistant bacteria develop a high level of resistance to multiple drugs, limiting treatment options and increasing morbidity and mortality. This work was planned to evaluate the antibacterial potential of the methanol extract from the whole plant of Kalanchoe crenata (KCW) against multidrug-resistant (MDR) Gram-negative bacteria.
Methods: The minimal inhibitory concentrations (MIC) and the minimal bactericidal concentrations (MBC) of KCW alone, in the presence of an e...
More