Abstract Background:This study assessed changes in blood chemistry associated with co-administration of chloroquine with antiplasmodial fraction of crude methanol extract of Moringa oleifera leaves. Methods: Partial phytochemical profiling of antiplasmodial extract was done using standard methods. Using Rane’s test, 60 male albino mice were randomized into 10 groups of six mice each. Nine groups were inoculated with quinine resistant strains of Plasmodium berghei and treated with tween 80,10mg/k...

Irene Chinda Kengne1, Jean-De-Dieu Tamokou1* Abstract Background: The increasing number of resistant bacteria to commonly used antibiotics makes the search for new active molecules a real challenge. The aim of this study is to evaluate the antibacterial activities of crude extracts and fractions from four Cameroonian medicinal plants against multi-resistant bacteria as well their mechanisms of action. Methods: The crude extracts were prepared by maceration in methanol. The fractionatio...

Abstract Background: Sickle cell anaemia (SCA) is a genetic disease associated with increased mortality in Africa. It generates polymerization of haemoglobin, free radicals proliferation and antioxidants deficiencies. SCA management still needs new and safe drugs. The aim of this study is to evaluate the antioxidant and anti-sickling properties of cocoa extracts from two localities of Cameroon. Methods: T. cacao beans were collected in Bertoua and Mbalmayo They were dried, ground and then...