Abstract
Background: The emergence and persistence of multidrug-resistant (MDR) bacteria appears today as a serious threat of growing concern to human health. The aim of this present study was to investigate the antibacterial and antibiotic-modulating activity of the methanol extracts of Manilkara zapota (L.) P. Royen (Sapotaceae) against pathogenic strains belonging to Gram-positive bacterium, Staphylococcus aureus, and Gram-negative bacteria.
Methods: The antibacterial activity as well ...
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Research article
Aqueous extracts of Desmodium adscendens (Fabaceae) possess in vitro antioxidant properties and protect hepatocytes from Carbone tetrachloride-induced injury and Hepatitis C Virus infection
Abstract
Background: Desmodium adscendens (DA) is an herbaceous plant found in Africa and South America and used in traditional medicine against liver-related diseases. In the present study, the aqueous decoctions from DA were tested for its antioxidant and hepato-(protective and curative) properties on CCl4-induced acute injury on primary culture rats’ hepatocytes. We also investigated its inhibitory effects on hepatitis C virus (HCV) using genotype 1b subgenomic replicon systems and cell-c...
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Antibacterial potential and mechanism of action of botanicals and phytochemicals from Stachytarpheta cayennensis (Verbenaceae) against Gram-negative multidrug-resistant phenotypes expressing efflux pumps
Abstract
Background: The effectiveness of antibiotics in the fight against bacterial infections motivated their massive use which resulted in the appearance of resistant bacteria. This phenomenon is nowadays in constant evolution and represents a major problem of public health. In this respect, the search for new molecules for fighting against bacterial resistance is essential. This work was committed to studying the in vitro antibacterial activity of the ethanol crude extract, fra...
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Antipsychotic and anticonvulsant effects of crude aqueous leaf extract of Vitex doniana Sweet (Verbenaceae) In mice
Abstract
Background: This work evaluated the antipsychotic and anticonvulsant effects of crude aqueous leaf extract of Vitex doniana in mice. This was to validate the use of V. doniana in the treatment of mental disorders and epilepsy in folkloric medicine.
Methods: Antipsychotic effect of V. doniana was evaluated using the animal models of psychosis: swimming-induced grooming, ketamine-induced hyperlocomotion and apomorphine-induced climbing tests. Anticonvulsant effect was evaluated usi...
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Acetylcholinesterase inhibitory, anti-inflammatory and antioxidant properties of some Cameroonian medicinal plants used to treat some neurological disorders
Abstract
Background: Besides the principal hallmark of Alzheimer’s disease (AD) and Parkinson’s disease (PD) which is accumulation of mis-folding protein in the brain; cholinergic deficit, neuro-inflammation and oxidative stress are also implicated the pathogenesis of the above-mentioned diseases. In the present study, different plant parts were collected in an ethnopharmacological survey carried out in the Noun Division (West Region, Cameroon).
Methods: A total of 29 methylene chloride-m...
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Investigation of antimicrobial and antioxidant properties of extracts of the stem bark of Drypetes floribunda (Euphorbiaceae)
Abstract
Background: The use of the stem bark of Drypetes floribunda in the treatment of microbial infections is common amongst the people of Kwahu Asakraka in the Eastern Region of Ghana. However not much studies have been done to establish the scientific basis of this and to isolate the bioactive principles from the stem bark. Objectives: To assess the antimicrobial and antioxidant properties of the stem bark and to isolate some bioactive principles and investigate their antimicrobial act...
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Antiproliferative properties of labdane diterpenoids from Croton sylvaticus Hochst against drug sensitive and resistant leukemia cell lines
Abstract
Background: Cancer treatment failure is majorly attributed to the emergency of multi-drug resistance of cancer cells towards most conventional drugs used in chemotherapy hence the need for more active principles with less side effective from natural sources.
Methods: Characterization of isolated compounds was achieved using NMR spectroscopy and comparison of acquired data with literature values. The antiproliferative properties were determined using resazurin reduction assay.
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Anti-leishmanial activity of some surface compounds of Tarchonanthus camphoratus
Abstract
Background:The world health organization recognizes leishmaniasis as a major tropical disease with no effective vaccine against it. Chemotherapy, the only effective way to treat all forms of the disease, is toxic and expensive. Hence, there is need for scientists to scale up the search for new anti-leishmanial agents. The present study investigated the in vitro anti-leishmanial activity of five surface compounds of Tarchonanthus camphoratus.
Methods: The surface exudates were obt...
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Sedative, Anticonvulsant and Analgesic activities of Fresh Leaf Essential Oil of Plectranthus aegyptiacus from Southwest Nigeria in Mice
Abstract
Background: The folkloric use of Plectranthus aegyptiacus (Forssk.) C. Chr. in the Southwest Nigeria includes;pain, sensory diseases, cough and fever. This study investigated the anxiolytic, sedative, anticonvulsant and analgesic activities of the essential oil of P.aegyptiacus in mice.
Methods: The oil was extracted by hydro-distillation.5% Tween-80 (0.1 ml/10 g)was used as negative control and different standard drugs were used as positive controls depending on the model. The ...
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Protective effect of ethanolic extract and raw juice of Solanum betaceum on aluminum induced oxidative stress and associated memory deficits in rats
Abstract
Background: Oxidative stress is known to contribute to the mechanisms underpinning the pathogenesis of neurodegenerative diseases. Previous studies have identified the presence of flavonoids as the major constituents of Solanum betaceum (SB) with antioxidant activity. This work aims at investigating the protective effect of ethanolic extract and raw juice of Solanum betaceum (SB) on aluminum induced oxidative stress and associated memory deficits in Wistar rats.
Methods: Memor...
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