In vivo antiplasmodial activity of extracts of selected Ghanaian medicinal plants

Abstract Background: Malaria is endemic and perennial in all parts of Ghana. Ghana recorded 4,940,270 suspected malaria cases in the first half of the year 2016. This translates into 26,922 as an average daily recorded case of malaria in the country’s health facilities during the period. Methods: This study investigated the antiplasmodial activities of aqueous extracts of the stem barks of Afraegle paniculata, Monanthotaxis trichocarpa, Sterculia setigera and Strychnos innocua as well as ...
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Plants- Drug Interactions Against Some Multi-drug Resistant Microorganisms Causing Urogenital Tract Infections in Cameroon

Investigational Medicinal Chemistry and Pharmacology 2018 1(1):4 Abstract Background: Multi drug resistance is an increasing phenomenon plaguing the use of antibiotics nowadays. This favors the spread of pathogenic microorganisms causing a major public health problem. Antimicrobial compounds from medicinal plants can be used synergistically to enhance the activity of standard drugs when used concurrently. The aim of this work was to evaluate the ability of extracts from Skirakiopsis ellip...
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Anti-nociceptive and Anti-inflammatory Effects of Gmelina arborea Roxb. e x. Sm.

Abstract Background: The aim of the present study was to evaluate the anti-inflammatory and anti-nociceptive activities of the methanolic extract of Gmelina arborea fruit (GAF) and stem bark (GASB) on egg-albumin induced inflammation and heated plate metal respectively. Methods: Five hundred grams of each of the pulverised samples was extracted with 90% methanol using soxhlet extractor to produce dense mass of methanolic extracts after distillation and kept in a refrigerator at 4oC until ...
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Polyphenolic extract of Paullinia pinnata leaf exhibits antidiabetic, anthyperlipidaemic and antioxidant activities in alloxan-induced diabetic rats

Abstract Background: This study evaluated the antidiabetic, antihyperlipidaemic and antioxidant effects of polyphenolic extract of Paullinia pinnata leaf (PEPPL) in alloxan-induced diabetic rats. Method: Diabetes was induced in Albino rats by intraperitoneal administration of alloxan monohydrate (120 mg/kg body weight (b. w.)). Male and female rats of average weight 150 ± 1.14 g were selected for the study. PEPPL at a dose of 25 and 50 mg/kg b. w. was administered single dose per day to a...
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Cytotoxicity of Lupeol from the Stem Bark of Zanthoxylum gilletii against Multi-factorial Drug Resistant Cancer Cell Lines

Investigational Medicinal Chemistry and Pharmacology 2018 1(1):10. Abstract Background: Drug resistance is one of the major hurdles in the treatment of cancer. Rather than single factors, drug resistance is caused by multiple mechanisms making it even more complex. In the present study, the cytotoxicity of six compounds isolated from Zanthoxylum gilletii were screened against drug-sensitive leukemia CCRF-CEM cells. The most cytotoxic compound, lupeol (1) was further tested in a panel of n...
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Hepatoprotective activities of Autranella congolensis and Sapium ellypticum against carbone tetrachloride induced liver injuries in experimental rats.

Abstract Background: Liver injury remains a serious problem worldwide despite advances in drug research. In the perspective of searching for new natural agents that can prevent such abnormalities this study was designed to evaluate the in vivo anti-oxidative properties of the methanolic extracts of Autranella congolensis and Sapium ellypticum. Methods: The hepatoprotective properties of the extracts were evaluated on 9 groups of 5 Wistar rats using the CCl4 model. Animals were treated oral...
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Anthelmintic resistance modifying properties of extracts of Cyperus difformis L. (Cyperiaceae)

Francis Adu1, Christian Agyare1*, George Henry Sam2, Yaw Duah Boakye1, Vivian Etsiapa Boamah1 Investigational Medicinal Chemistry and Pharmacology 2018 1(1):3 Abstract Background: Resistance by parasites to anthelmintic drugs is known to be on the increase and little attention is paid to the subject. The aim of study was to determine the anthelmintic and helminth resistance modifying activities of methanol whole plant Cyperus difformis extract against the adult Indian worm Pherethima p...
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Catechin Derivatives from Parkia biglobosa Displayed Selective Cytotoxicity Towards Leukemia CCRF-CEM Cell Line and its P-Glycoprotein Expressing Subline CEM/ADR5000

Investigational Medicinal Chemistry and Pharmacology 2018; 1(1):2 Abstract Background: Cancer chemotherapy is challenged by drug resistance of malignant cells. In the present work, we evaluated the cytotoxicity of four catechin derivatives, 4’-methylepigallocatechin (1), gallocatechin (2), epigallocatechin (3), epigallocatechin-3-O-gallate (4) against nine drug sensitive and multidrug resistant (MDR) cancer cell lines. Methods: The resazurin reduction assay was used to evaluate the cyt...
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Anti-staphylococcal and antibiotic-potentiating activities of seven Cameroonian edible plants against resistant phenotypes

Hermione T. Manekeng1, Armelle T. Mbaveng1*, Gaelle S. Nguenang1, Jackson A. Seukep1, Brice E. N. Wamba1, Paul Nayim1, Ngai R. Yinkfu1, Aimé G. Fankam1 and Victor Kuete1 Investigational Medicinal Chemistry and Pharmacology 2018 1(1):7 Abstract Background: In this study, we evaluated the anti-staphylococcal and antibiotic-potentiating activities against resistant phenotypes of seven Cameroonian dietary plants: Arachis hypogaea; Cola pachycarpa; Curcuma longa; Lycopersicon esculentum; Ma...
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Potentiation of chloroquine by antiplasmodial fraction of moringa oleifera leaves in drug resistant Plasmodium berghei infection

Abstract Background:This study assessed changes in blood chemistry associated with co-administration of chloroquine with antiplasmodial fraction of crude methanol extract of Moringa oleifera leaves. Methods: Partial phytochemical profiling of antiplasmodial extract was done using standard methods. Using Rane’s test, 60 male albino mice were randomized into 10 groups of six mice each. Nine groups were inoculated with quinine resistant strains of Plasmodium berghei and treated with tween 80,10mg/k...
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