Abstract
Background: Klebsiella has developed multiple-drug resistance (MDR) to a wide range of medicines, including carbapenems and third generation cephalosporins which are often regarded as the most effective drugs against MDR bacteria. The present study examined the anti-klebsiella, modes of action, and antibiotic-resistance reversal potential of Syzygium jambos (Myrtaceae) leaf (SJL) and bark (SJB) methanol extracts towards a panel of sixteen MDR K. pneumoniae and K. oxytoca strains and...
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Inorganic Compounds Utilized in Cancer Therapy: A Comprehensive Review
-Ioana Babarus; Ionut-Iulian Lungu; Alina Stefanache
Abstract
Background: Cancer is the most feared disease, with more than 1.6 million cases yearly. Cancer can start almost anywhere in the human body, from the uncontrollable growth and multiplication of damaged cells. Cancerous tumors can spread into the human body (a process called metastasis) in a solid form usually, but the cancers of the blood generally do not.
Methods: The review analyzes a wide range of scientific literature and research studies to assess the efficacy and mechanisms ...
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Psidium guajava (Myrtaceae) re-sensitizes multidrug-resistant Pseudomonas aeruginosa over-expressing MexAB-OprM efflux pumps to commonly prescribed antibiotics
-Romario S. Tiotsop; Armelle T. Mbaveng; Armel Jackson Seukep; Valaire Y. Matieta; Paul Nayim, Brice E. N. Wamba; Michel-Gael F. Guefack; Victor Kuete
Abstract
Background: Pseudomonas aeruginosa is a critical-class priority pathogen showing high resistance to almost all classes of conventional antibiotics. As a result, discovering new drugs capable of combating Pseudomonas infections becomes critical. The current study looked at the antibacterial and antibiotic-resistance reversal properties of the leaf (PGL) and bark (PGB) methanol extracts of Psidium guajava (Myrtaceae), a popular food plant, towards multidrug-resistant (MDR) P. aeruginosa ...
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In vivo assessment of antidiabetic activity and safety of polyherbal teas from selected Cameroonian medicinal plants: Persea americana, Ageratum conyzoides, and Mangifera indica
-Denis Zofou; Emmanuella Ekuri Matumamboh; Golda Shu; Faustin Pascal Tsague Manfo; Clautilde Teugwa Mofor; David Denis Sofeu Feugaing; Aduni Ufuan Achidi; Jules-Clement Nguedia Assob; and Josepha Foba Tendo.
Background: Diabetes mellitus (DM) is a metabolic disorder of the endocrine system which results in persistently high blood glucose levels. Available control measures do not completely cure the disease and most patients in the tropics cannot afford diabetes drugs regularly. Amongst other plants, Mangifera indica (MI), Persea americana (PA), and Ageratum conyzoides (AC) are used individually as traditional medicine by most people for the management of diabetes. This work was set to produce polyhe...
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Antibacterial potential and modes of action of botanicals from Momordica foetida (Cucurbitaceae) against multidrug-resistant bacteria expressing active efflux pumps
-Cedric F. Tchinda; Olive Monique F. Demgne; Armelle T. Mbaveng; Veronique P. Beng; Victor Kuete
Abstract
Background: Momordica foetida (cucurbitaceae) known as a bitter cucumber in Cameroon is used as a medicinal plant. This plant is widely used in the treatment of microbial infections, diabetes, hypertension, stomach, and intestinal irritation. The leaves are also used to treat malaria, earache, and toothache. This study aimed at investigating the antibacterial activity of the methanol extract of M. foetida seeds against multidrug-resistant bacteria expressing active efflux pumps and ...
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Antiproliferative, antimicrobial, antiplasmodial, and oral acute toxicity of Ficus elastica Roxb. Ex Hornem lianas
-Jean Emmanuel Mbosso Teinkela; Gaelle Wea Tchepnou; Caroline Ngo Nyobe; Yannick Fouokeng; Emmanuel Mpondo Mpondo; Jules Clément Assob Nguedia
Abstract
Background: Ficus elastica is a plant used in traditional medicine for the treatment of allergies and skin infections. This study aimed to investigate the antimicrobial, antiplasmodial, and antiproliferative activities of the crude extract and fraction of F. elatica as well as the study of the in vivo oral acute toxicity of the most active fraction.
Methods: The antimicrobial activity of the total extract and the different fractions was evaluated by the determination of the inhib...
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Phytochemistry and pharmacology of Imperata cylindrica: A comprehensive review
-Paul Nayim; Armelle T. Mbaveng; Krishna Sudhir; Brice E. N. Wamba; Mukherjee Sanjukta; Kuete V.
Abstract
Background: Imperata cylindrica is a medicinal spice used in traditional medicine to cure several ailments including cancer, wounds, hypertension, and inflammation. The current study aimed to compile phytochemicals and pharmacological data on Imperata cylindrica.
Methods: A bibliographic study was carried out by analyzing conventional textbooks, authentic published studies, and consulting wide-reaching accepted scientific databases. In this review, an attempt is being made to est...
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Anti-staphylococcal and antibiotic-potentiating activities of botanicals from nine Cameroonian food plants towards multidrug-resistant phenotypes
-Boris Ekamgue; Armelle T. Mbaveng; Victor Kuete
Abstract
Background: Staphylococcus aureus is a commensal and pathogenic bacterium responsible for both community and nosocomial infections, superficial or deep, and benign or lethal. Staphylococcus aureus is a commensal and pathogenic bacterium responsible for both community and nosocomial infections, superficial or deep, and benign or lethal. Because of its infectious potential and its ability to develop resistance to many antibiotics, staphylococcal infections remain the target of reinfor...
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Botanicals from nine selected Cameroonian edible plants displayed Anti-pseudomonas effects and potentiated the activities of antibiotics against multidrug-resistant phenotypes over-expressing MexAB-OprM efflux pumps
-Romario S. Tiotsop; Victor Kuete; Armelle T. Mbaveng
Abstract
Background: Despite the recognized efficiency of antibiotic therapy, the annual cases of deaths related to bacterial diseases is still growing in developing countries. In the present study, the in vitro antipseudomonal activity of the methanol extracts of nine food plants from Cameroon against the multidrug-resistant strains and isolates of Pseudomonas aeruginosa overexpressing active efflux pumps was determined. These plants included Persea americana, Syzygium jambos, Mangifera ind...
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Anti-Klebsiella and antibiotic-potentiation activities of the methanol extracts of seven Cameroonian dietary plants against multidrug-resistant phenotypes over-expressing AcrAB-TolC efflux pumps
-Valaire Y. Matieta, Victor Kuete; Armelle T. Mbaveng
Abstract
Background: Bacterial infections continue to wreak havoc around the world with high death rates. African medicinal plants and the phytoconstituents showed high efficiency in impeding the growth of the resistance phenotypes of bacteria The present work was designed to determine the antibacterial activity of seven Cameroonian dietary plants against clinical MDR isolated of Klebsiella sp. These plants included Persea americana Miller (Lauraceae), Psidium guajava Linn. (Myrtaceae), Mang...
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