Abstract
Background: Vietnam is a tropical country blessed with many plants. The majority of these floras have not been exploited for their chemical constituents and biological potential. In an attempt to source for natural products to combat microbial infections, plant products can act in this regard. The aim of this paper was to report the chemical composition and antimicrobial activity of essential oil from Amomum glabrum growing in Vietnam.
Methods: The leaves and rhizomes of Amomum g...
More
Characterization of phytochemicals from the root extract of Milletia leucantha and their weak anti-microbial properties
Abstract
Background: Cures for infectious diseases are slowly becoming elusive due to resistance mechanisms of disease-causing microbes. As a result, most conventional medicines are now being rendered ineffective, causing increased difficulty in the treatment of infections and an upsurge of fatalities. In the present study, the anti-bacterial and anti-fungal properties of extracts and compounds of Milletia leucantha were investigated.
Methods: The roots of M. leucantha were exhaustively e...
More
Investigation of the antihyperlipidemic property of Raphia hookeri mesocarp oil in high-lard diet (HLD) fed rats
Abstract
Background: Dyslipidemia is an important risk factor cardiovascular disease. The mesocarp of R. hookeri has been shown to resemble that of palm oil in term oil quality, with a large quantity of linoleic acid (47.3%) followed by palmitic acid (32.3%), oleic acid (13.7%) and alpha-linolenic acid (1.1%). The present investigation aimed to evaluate the antihyperlipidemic property of crude Raphia hookeri mesocarp oil in male Wistar albino rats fed with high-lard diet (HLD).
Methods:...
More
Antidepressant potential of butanol fraction of Milicia excelsa (Moraceae) leaf in mice
Abstract
Background: Milicia excelsa is used to treat mental illnesses among the Hausa ethnic group of Northern Nigeria, but there is lack of scientific investigation to validate this ethnomedicinal claim. Hence, this study investigated the antidepressant-like effect of butanol fraction of Milicia excelsa leaves in mice (BFME).
Methods: The antidepressant-like effect of BFME was investigated using forced swim (FST) and tail suspension (TST) tests in mice. The probable neural mec...
More
Antibacterial, antioxydant and antidiarrheal properties of Tristemma hirtum P. beauv.
Abstract
Background: The aim of this study was to investigate the antibacterial, radical-scavenging and antidiarrheal properties of Tristemma hirtum.
Methods: The methanol extract of Tristemma hirtum was prepared by successive fractionation in hexane and ethyl acetate solvents. The phytochemical composition of crude extract and fractions was studied using standard methods. Their antimicrobial activities were evaluated against Gram-negative and Gram-positive species of pathogenic bacteria ...
More
Table of Contents _ Volume3, issue 1; July 31, 2020
Volume3, issue 1; July 31, 2020
(Available at: https://www.investchempharm.com/volume/volume3/issue-1/)
https://dx.doi.org/10.31183/imcp.2020.v3i1
Research Article
1- Antipsychotic and anticonvulsant effects of crude aqueous leaf extract of Vitex doniana Sweet (Verbenaceae) In mice
Authors: Joshua Oloruntobi Imoru, Idris Ajayi Oyemitan and Atanda Moses Akanmu. Investigational Medicinal Chemistry and Pharmacology 2020 3(1):35. doi: https://dx.doi.org/10.31183/imcp.2020.00034
...
More
Antimicrobial and antioxidant activities of isolated compounds from the root bark of Croton pseudopulchellus (Euphorbiaceae)
Abstract
Background: Despite the significant progress made in microbiology and the control of microorganisms, sporadic incidents of epidemics due to drug resistant microorganisms pose an enormous threat to public health. Hence, search for new antimicrobial is very important to overcome microbial resistance and emerging pathogenic bacteria and fungi. In this study, we designed to describe the isolation, structure elucidation, antimicrobial and antioxidant activities of components from the roo...
More
Anti-amnesic effect of ethanol stem bark extract and fractions of Milicia excelsa (Moraceae) in mice
Abstract
Background: Amnesia is associated with normal aging and neuropsychiatric disorders with no known medical cure. Medicinal plants used in traditional medicines to combat neuropsychiatric disorders may be a veritable vehicle towards providing the appropriate drug candidate(s).
Methods: Hence, this study assessed the anti-amnesic potential of Milicia excelsa stem bark upon its widespread use in traditional medicine for treating mental illnesses. The anti-amnesic potentials of ethanol...
More
Methanol Extracts from Manilkara zapota with Moderate Antibacterial Activity Displayed Strong Antibiotic-Modulating Effects against Multidrug-Resistant Phenotypes
Abstract
Background: The emergence and persistence of multidrug-resistant (MDR) bacteria appears today as a serious threat of growing concern to human health. The aim of this present study was to investigate the antibacterial and antibiotic-modulating activity of the methanol extracts of Manilkara zapota (L.) P. Royen (Sapotaceae) against pathogenic strains belonging to Gram-positive bacterium, Staphylococcus aureus, and Gram-negative bacteria.
Methods: The antibacterial activity as well ...
More
Aqueous extracts of Desmodium adscendens (Fabaceae) possess in vitro antioxidant properties and protect hepatocytes from Carbone tetrachloride-induced injury and Hepatitis C Virus infection
Abstract
Background: Desmodium adscendens (DA) is an herbaceous plant found in Africa and South America and used in traditional medicine against liver-related diseases. In the present study, the aqueous decoctions from DA were tested for its antioxidant and hepato-(protective and curative) properties on CCl4-induced acute injury on primary culture rats’ hepatocytes. We also investigated its inhibitory effects on hepatitis C virus (HCV) using genotype 1b subgenomic replicon systems and cell-c...
More