Abstract Background: Cisplatin is one of the most effective antineoplastic drugs, but it has undesirable side effects such as hepatotoxicity. This study investigated in vitro the protective activity of three limonoids known as 17-epi-methyl-6-hydroxylangolensate, 7-deacetoxy-7-oxogedunin and deacetoxy-7R-hydroxygedunin, isolated from Khaya grandifoliola (Meliaceae) against cisplatin-induced hepatotoxicity and the possible mechanisms involved in this activity. Methods: Normal human liver...