Antidepressant-like eﬀects of the aqueous lyophilizate of the roots bark of Capparis sepiaria (Capparaceae) on an animal’s model of depression

-Francis Bray Yassi; Gwladys Temkou Ngoupaye; Stephanie Jacqueline Kameni Njapdounke; Tatiana Diebo Kom; Maxwell Blesdel Adassi; Aurelien Fossueh Foutsop; Elisabeth Ngo Bum.

Abstract Background: Major Depressive Disorder is a common mental illness characterized by persistent low mood, cognitive impairment, anhedonia, weight gain, or loss and several other symptoms, ranging from psychomotor to cognitive impairments. Commonly available antidepressants show side effects and limited efficacy; therefore, an alternative is to be considered. Capparis sepiaria (Capparaceae) is a plant used in traditional medicine to treat mental disorders. The aim of this study was to i...

Exploring Mangifera indica (Anacardiaceae) leaf and bark methanol extracts as potential adjuvant therapy in the management of multidrug-resistant Staphylococcus aureus

-Boris Ekamgue; Armelle T. Mbaveng; Armel J. Seukep; Valaire Y. Matieta; Jenifer R. N. Kuete; Junior F. Megaptche; Michel-Gael F. Guefack; Paul Nayim; Victor Kuete.

Abstract Background: After several decades of antibiotic use, pathogenic bacteria have reached alarming levels of resistance. Staphylococcus aureus is the most common cause of nosocomial infections, and treatment is difficult owing to the advent of multidrug-resistant (MDR) strains. This motivates the search for more potent drugs. Foremost, adjuvant compounds that increase the effectiveness of conventional antibiotics are also being researched extensively. The current study examined the anti...

Effect of vitamin D supplementation on the efficacy of anti-diabetic drugs in streptozotocin- induced albino Wistar rat model

-Denis Zofou; Hostin Nahbum Mua; Golda Shu Lum; Sirri Kelley Ambe; Ngutanu Sandrine Asaba; Denis D. F. Sofeu; Clautilde Teugwa Mofor

Abstract Background: Diabetes mellitus (DM) is a major health challenge that has reached alarming levels worldwide; and due to limitations of existing therapies, the disease has remained an enduring public threat for several decades. Vitamin D deficiency has been shown to play an important role in the pathogenesis of diabetes mellitus as it can affect several key processes in the development of diabetes and its complications, such as pancreatic insulin secretion, peripheral insulin resistanc...

Unveiling the antibacterial potential and antibiotic-resistance breaker activity of Syzygium jambos (Myrtaceae) towards critical-class priority pathogen Klebsiella isolates

-Valaire Y. Matieta; Armel J. Seukep; Jenifer R. N. Kuete; Junior F. Megaptche; Michel-Gael F. Guefack; Paul Nayim; Armelle T. Mbaveng; Victor Kuete.

Abstract Background: Klebsiella has developed multiple-drug resistance (MDR) to a wide range of medicines, including carbapenems and third generation cephalosporins which are often regarded as the most effective drugs against MDR bacteria. The present study examined the anti-klebsiella, modes of action, and antibiotic-resistance reversal potential of Syzygium jambos (Myrtaceae) leaf (SJL) and bark (SJB) methanol extracts towards a panel of sixteen MDR K. pneumoniae and K. oxytoca strains and...

Inorganic Compounds Utilized in Cancer Therapy: A Comprehensive Review

-Ioana Babarus; Ionut-Iulian Lungu; Alina Stefanache

Abstract Background: Cancer is the most feared disease, with more than 1.6 million cases yearly. Cancer can start almost anywhere in the human body, from the uncontrollable growth and multiplication of damaged cells. Cancerous tumors can spread into the human body (a process called metastasis) in a solid form usually, but the cancers of the blood generally do not. Methods: The review analyzes a wide range of scientific literature and research studies to assess the efficacy and mechanisms ...

Psidium guajava (Myrtaceae) re-sensitizes multidrug-resistant Pseudomonas aeruginosa over-expressing MexAB-OprM efflux pumps to commonly prescribed antibiotics

-Romario S. Tiotsop; Armelle T. Mbaveng; Armel Jackson Seukep; Valaire Y. Matieta; Paul Nayim, Brice E. N. Wamba; Michel-Gael F. Guefack; Victor Kuete

Abstract Background: Pseudomonas aeruginosa is a critical-class priority pathogen showing high resistance to almost all classes of conventional antibiotics. As a result, discovering new drugs capable of combating Pseudomonas infections becomes critical. The current study looked at the antibacterial and antibiotic-resistance reversal properties of the leaf (PGL) and bark (PGB) methanol extracts of Psidium guajava (Myrtaceae), a popular food plant, towards multidrug-resistant (MDR) P. aeruginosa ...

In vivo assessment of antidiabetic activity and safety of polyherbal teas from selected Cameroonian medicinal plants: Persea americana, Ageratum conyzoides, and Mangifera indica

-Denis Zofou; Emmanuella Ekuri Matumamboh; Golda Shu; Faustin Pascal Tsague Manfo; Clautilde Teugwa Mofor; David Denis Sofeu Feugaing; Aduni Ufuan Achidi; Jules-Clement Nguedia Assob; and Josepha Foba Tendo.

Background: Diabetes mellitus (DM) is a metabolic disorder of the endocrine system which results in persistently high blood glucose levels. Available control measures do not completely cure the disease and most patients in the tropics cannot afford diabetes drugs regularly. Amongst other plants, Mangifera indica (MI), Persea americana (PA), and Ageratum conyzoides (AC) are used individually as traditional medicine by most people for the management of diabetes. This work was set to produce polyhe...

Antibacterial potential and modes of action of botanicals from Momordica foetida (Cucurbitaceae) against multidrug-resistant bacteria expressing active efflux pumps

-Cedric F. Tchinda; Olive Monique F. Demgne; Armelle T. Mbaveng; Veronique P. Beng; Victor Kuete

Abstract Background: Momordica foetida (cucurbitaceae) known as a bitter cucumber in Cameroon is used as a medicinal plant. This plant is widely used in the treatment of microbial infections, diabetes, hypertension, stomach, and intestinal irritation. The leaves are also used to treat malaria, earache, and toothache. This study aimed at investigating the antibacterial activity of the methanol extract of M. foetida seeds against multidrug-resistant bacteria expressing active efflux pumps and ...

Antiproliferative, antimicrobial, antiplasmodial, and oral acute toxicity of Ficus elastica Roxb. Ex Hornem lianas

-Jean Emmanuel Mbosso Teinkela; Gaelle Wea Tchepnou; Caroline Ngo Nyobe; Yannick Fouokeng; Emmanuel Mpondo Mpondo; Jules Clément Assob Nguedia

Abstract Background: Ficus elastica is a plant used in traditional medicine for the treatment of allergies and skin infections. This study aimed to investigate the antimicrobial, antiplasmodial, and antiproliferative activities of the crude extract and fraction of F. elatica as well as the study of the in vivo oral acute toxicity of the most active fraction. Methods: The antimicrobial activity of the total extract and the different fractions was evaluated by the determination of the inhib...

Phytochemistry and pharmacology of Imperata cylindrica: A comprehensive review

-Paul Nayim; Armelle T. Mbaveng; Krishna Sudhir; Brice E. N. Wamba; Mukherjee Sanjukta; Kuete V.

Abstract Background: Imperata cylindrica is a medicinal spice used in traditional medicine to cure several ailments including cancer, wounds, hypertension, and inflammation. The current study aimed to compile phytochemicals and pharmacological data on Imperata cylindrica. Methods: A bibliographic study was carried out by analyzing conventional textbooks, authentic published studies, and consulting wide-reaching accepted scientific databases. In this review, an attempt is being made to est...