Chemical constituents and antibacterial activity from the fruits of Ficus sur Forssk

-Faustine L. M. Dongmo; Gabriel T. Kamsu; Arno R. D. Nanfack; Blanche L. Ndontsa; Rabia Farooq; Gabin T. M. Bitchagno; Atia-tul-Waha; Mathieu Tene.

Abstract Background: Ficus sur Forssk is used in traditional African medicine in the treatment of skin diseases, epilepsy, jaundice, pain, inflammation, anemia, sexually transmitted diseases, and diarrhea. We described here the chemical study and antibacterial properties of F. sur ethanol extract. Methods: Separation and isolation of compounds were performed using common chromatographic methods. The structures of compounds were determined by spectrometric and spectroscopic analyses includ...

Antifungal activity of endophytic Fusarium oxysporum from Cola acuminata against Candida albicans isolates from HIV-infected patients

-Pythagore S. Fogue; Heroine M. Mfouapon; Rufin M. K. Toghueo; Victor Sini; Jules-Roger Kuiate.

Abstract Background: The Human Immunodeficiency Virus (HIV) infection has exacerbated the occurrence of opportunistic diseases with Candida infection being the most prominent. Unfortunately, the growing ineffectiveness of the available antifungal drugs along with the emergence of new multi-resistant strains further worsen the matter. In the search for new active molecules, the present study aims at investigating the optimal growth conditions for the production of antifungal metabolites from ...

Antibacterial and antibiotic-potentiating activities of Desmodium uncinatum, Neoboutonia glabrescens, Ternstroemia cameroonensis and eight other Cameroonian medicinal plants against multi-drug resistant bacteria expressing active efflux pumps

-Achille C. Kofogoue; Cedric F. Tchinda; Victor Kuete

Abstract Background: Infectious diseases remain a major public health problem in the world with a considerable impact in developing countries. Bacterial infections are of increasing concern due to the emergence and spread of bacteria resistant to antibiotics. Thus, it is necessary to develop methods and means to tackle drug resistance. The present study aimed at evaluating the antibacterial and antibiotic-potentiating activities of eleven Cameroonian medicinal plants: Sambucus nigra, Erigero...

Antibacterial and antibiotic-modulating activities of Rhinella jimi and three other animal extracts against multidrug-resistant Gram-negative phenotypes

-Michel-Gael F. Guefack; Simplice B. Tankeo; Carine M.N. Ngaffo; Idrios N. Bonsou; Paul Nayim; Brice E.N. Wamba; Victor Kuete; Armelle T. Mbaveng.

Abstract Background: The antibiotic resistance of pathogenic bacteria is one of the major health problems worldwide. The development of novel antimicrobial therapies based on natural products that greatly reduce this resistance is urgent. The present study aimed at evaluating the antimicrobial potential of four animal methanol extracts, Gryllus campestris, Testudo hermanni, Cardisoma guanhumi, and Rhinella jimi as well as their synergistic effects with antibiotics against twenty Gram-negativ...

Modes of action of the methanol extract and 3-O-[β-galactopyranosyl-(1→4)-β-D-galactopyranosyl]-oleanolic acid from Acacia polyacantha against multidrug-resistant Gram-negative bacteria

-Flora T. Mambe; Cedric F. Tchinda; Brice E. N. Wamba; Paul Nayim; Fred Ashu; Hermione T. Manekeng; Veronique P. Beng; Victor Kuete.

Abstract Background: Bacterial infections, especially those caused by multidrug-resistant (MDR) Gram-negative bacteria, remain a global health concern. Previous studies have reported the antibacterial activities of the methanol extract of the leaves of Acacia polyacantha Willd. (Fabaceae) (APL) as well as some of its phytoconstituents. In this study, APL and its constituent, 3-O-[β-galactopyranosyl-(1→4)-β-D-galactopyranosyl]-oleanolic acid (GGOA) were evaluated on growth kinetics, bacterial...

Analgesic and anti-inflammatory activities of roots aqueous extract of Pseudospondias microcarpa (A. Rich.) Engl. (Anarcadiaceae) in mice and rats

-Edwige L. Nguemfo; Henriette P. M. Ngoualeu; Annie L. F. Magne; Calvin Z. Bogning; Anatole G. B. Azebaze; Alain B. Dongmo.

Abstract Background: Pseudospondias microcarpa (P. microcarpa) is a tree belonging to the family Arnacardiaceae. This species is used in traditional medicine to treat pain, inflammation, malaria, and skin diseases. The present study was undertaken to evaluate the analgesic and anti-inflammatory properties of the aqueous extract of P. microcarpa roots. Methods: Swiss mice and Wistar albino rats were used for the study. The aqueous extract (100, 300, and 600 mg/kg), standards, and water wer...

Antibacterial and antibiotic-potentiating activities of nine Cameroonian medicinal plants against multidrug-resistant bacteria expressing active efflux pumps

-Olive Monique F. Demgne; Cedric F. Tchinda; Armelle T. Mbaveng; Veronique P. Beng; Victor Kuete

Abstract Background: In the last ten years, the resistance of Gram-negative and Gram-positive bacteria continuously increased. The present study was designed to evaluate the antibacterial and antibiotic-potentiating activities of nine Cameroonian medicinal plants: Cucumeropsis mannii, Lagenaria siceraria, Citrullus lanatus, Cucurbita moschata, Salix ledermannii, Gouania longispicata, Psychotria mapourioides, Conyza aethiopica and Conyza sumatrensis against resistant phenotypes. Methods: L...

Efficacy and persistence of essential oil of Monodora myristica against Anopheles gambiae, the main vector of malaria in sub-Saharan Africa

- Henri G. Tsila ; Patrick Akono Ntonga; Suzanne C. Lemogo Magnouet ; Timoléon Tchuinkam.

Abstract Background: Monodora myristica known as calabash or nutmeg, is a tree of the Annonaceae family whose seeds are mainly used as a spice. The control of malaria is still a challenge partly due to mosquito resistance to conventional insecticides. The present work aimed to evaluate the insecticidal effect of the essential oil of M. myristica seeds to enlarge the list of local plants that can be used as insecticides. Methods: Essential oil was extracted by hydrodistillation using the C...