Abstract
Background: The emergence and spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly those overexpressing efflux pumps, make treatment difficult using conventional antibiotics. This study aims to assess the antibacterial activity of methanol extracts (botanicals) from the leaves (BSL) and bark (BSB) of Blighia sapida against a panel of MDR bacteria that overexpress efflux pumps.
Methods: Phytochemical screening of botanicals was carried out using standard qualit...
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Archives
Volume7, issue 3; December 31; 2024
https-dx-doi-org-10-31183-imcp-2024-v7i3
1- Unveiling the anti-Klebsiella activity of methanol extracts from Hallea ciliata leaves and barks against multidrug-resistant strains overexpressing AcrAB-TolC efflux pumps
Authors: Derick J. Assonfack; Larissa Mpude; Eric Cadet; Ancela W. B. Yendze; Valaire Y. Matieta; Jenifer R. N. Kuete; Junior F. Megaptche; Idrios N. Bonsou; Michael F. Kengne, Victor Kuete; and Armelle T. Mbaveng. Investigational Medicinal Chemistry and Pharmacology 2024 7(3):98. doi: https://dx.doi.org/10.31183/imcp.2024.00098
2- Antibacterial and antibiotic-potentiation activities of methanol extracts from Blighia sapida K. D. Koenig (Sapindaceae) against Gram-negative multidrug-resistant bacteria overexpressing efflux pumps
Authors: Ancela W. B. Yendze1, Larissa Mpude; Eric Cadet; Derick J. Assonfack; Valaire Y. Matieta; Jenifer R. N. Kuete; Junior F. Megaptche; Idrios N. Bonsou; Michael F. Kengne; Armelle T. Mbaveng; and Victor Kuete. Investigational Medicinal Chemistry and Pharmacology 2024 7(3):99. doi: https://dx.doi.org/10.31183/imcp.2024.00099
Unveiling the anti-Klebsiella activity of methanol extracts from Hallea ciliata leaves and barks against multidrug-resistant strains overexpressing AcrAB-TolC efflux pumps
Abstract
Background: Infectious diseases are considered one of the most critical threats to public health. The present work aimed to determine the anti-Klebsiella activity of methanol extracts (botanicals) of Hallea ciliata leaves (HCL) and bark (HCB) against multidrug-resistant phenotypes over-expressing ACrAB-TolC efflux pumps.
Methods: The antibacterial activity of botanicals alone and in combination with PAβN and antibiotics, was determined using the broth microdilution method. The ef...
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