Abstract
Background: Heavy metals such as lead are considered a toxicant that can cause multiple organ complications including cancer, liver disease, renal diseases, neurodegenerative diseases, and reproductive diseases. In pursuit of a low-cost and easily accessible antidote, this research examined the role of Pericopsis laxiflora extract in acute lead poisoning in Sprague-Dawley rats.
Methods: Liver damage was caused in animal studies by inducing lead acetate (50 mg/kg daily, intraperit...
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Archives
Volume7, issue 3; December 31; 2024
https-dx-doi-org-10-31183-imcp-2024-v7i3
1- Unveiling the anti-Klebsiella activity of methanol extracts from Hallea ciliata leaves and barks against multidrug-resistant strains overexpressing AcrAB-TolC efflux pumps
Authors: Derick J. Assonfack; Larissa Mpude; Eric Cadet; Ancela W. B. Yendze; Valaire Y. Matieta; Jenifer R. N. Kuete; Junior F. Megaptche; Idrios N. Bonsou; Michael F. Kengne, Victor Kuete; and Armelle T. Mbaveng. Investigational Medicinal Chemistry and Pharmacology 2024 7(3):98. doi: https://dx.doi.org/10.31183/imcp.2024.00098
2- Antibacterial and antibiotic-potentiation activities of methanol extracts from Blighia sapida K. D. Koenig (Sapindaceae) against Gram-negative multidrug-resistant bacteria overexpressing efflux pumps
Authors: Ancela W. B. Yendze1, Larissa Mpude; Eric Cadet; Derick J. Assonfack; Valaire Y. Matieta; Jenifer R. N. Kuete; Junior F. Megaptche; Idrios N. Bonsou; Michael F. Kengne; Armelle T. Mbaveng; and Victor Kuete. Investigational Medicinal Chemistry and Pharmacology 2024 7(3):99. doi: https://dx.doi.org/10.31183/imcp.2024.00099^
3- Protective effect of hydroethanolic leaves extract of Solanum macrocarpon on Cisplatin-induced kidney injury in rats
Authors: Godwin Agbeka; Grace Aba Bart-Plange; Akosua Pokuah; Mercy Aning Ampofo; Janet Akorkor Kwetey; Mathew Bimpong; Ama Agyeiwaa Anyimadu; Gloria Asem; Naomi Mensah; Jeffery Kweku Dadson; Christopher Larbie; Paul Poku Sampene Osei; Shadrack Donkor Benjamin O. Emikpe. Investigational Medicinal Chemistry and Pharmacology 2024 7(3):100. doi: https://dx.doi.org/10.31183/imcp.2024.00100
4- Botanicals from the flowers of Vernonia calvoana and the leaves of Senna spectabilis showed anti-Klebsiella activity and potentiated the activity of antibiotics against multidrug-resistant phenotypes overexpressing efflux pumps
Authors: Derick J. Assonfack; Eric Cadet; Larissa Mpude; Ancela W. B. Yendze; Valaire Y. Matieta; Jenifer R. N. Kuete; Junior F. Megaptche; Idrios N. Bonsou; Michael F. Kengne; Armelle T. Mbaveng; Victor Kuete. Investigational Medicinal Chemistry and Pharmacology 2024 7(3):101. doi: https://dx.doi.org/10.31183/imcp.2024.00101
5- Pericopsis laxiflora (Baker) Stem bark extract ameliorates acute Lead-induced hepatotoxicity: Modulation of Oxidative Stress and Inflammatory Pathways
Authors: Frederick Sarfo-Antwi; Christopher Larbie; Benjamin Obukowho Emikpe; Regina Appiah–Opong. Investigational Medicinal Chemistry and Pharmacology 2024 7(3):102. doi: https://dx.doi.org/10.31183/imcp.2024.00102
Botanicals from the flowers of Vernonia calvoana and the leaves of Senna spectabilis showed anti-Klebsiella activity and potentiated the activity of antibiotics against multidrug-resistant phenotypes overexpressing efflux pumps
Abstract
Background: The alarming trend of infectious diseases in public health is mainly due to bacterial multidrug resistance, the emergence of which is partly caused by the inappropriate use of antibiotics. Bacteria of the Klebsiella genus have acquired a priority level of resistance to antibiotics, reducing their effectiveness. The aim of this study was to evaluate the anti-Klebsiella activity of methanol extracts of Vernonia calvoana flowers and Senna spectabilis leaves against multidru...
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Protective effect of hydroethanolic leaves extract of Solanum macrocarpon on Cisplatin-induced kidney injury in rats
Abstract
Background: Nephrotoxicity is a common kidney condition affecting many people worldwide, with conventional synthetic drugs not often yielding desirable results. This study, therefore, aimed to assess the protective effect of Solanum macrocarpon on Cisplatin-induced nephrotoxicity in Wistar rats.
Methods: Hydroethanolic extract of the leaves of S. macrocarpon was prepared and analyzed for basic phytochemical constituents. Cisplatin (5 mg/kg) was administered to induce nephrotoxici...
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Antibacterial and antibiotic-potentiation activities of methanol extracts from Blighia sapida K. D. Koenig (Sapindaceae) against Gram-negative multidrug-resistant bacteria overexpressing efflux pumps
Abstract
Background: The emergence and spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly those overexpressing efflux pumps, make treatment difficult using conventional antibiotics. This study aims to assess the antibacterial activity of methanol extracts (botanicals) from the leaves (BSL) and bark (BSB) of Blighia sapida against a panel of MDR bacteria that overexpress efflux pumps.
Methods: Phytochemical screening of botanicals was carried out using standard qualit...
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Unveiling the anti-Klebsiella activity of methanol extracts from Hallea ciliata leaves and barks against multidrug-resistant strains overexpressing AcrAB-TolC efflux pumps
Abstract
Background: Infectious diseases are considered one of the most critical threats to public health. The present work aimed to determine the anti-Klebsiella activity of methanol extracts (botanicals) of Hallea ciliata leaves (HCL) and bark (HCB) against multidrug-resistant phenotypes over-expressing ACrAB-TolC efflux pumps.
Methods: The antibacterial activity of botanicals alone and in combination with PAβN and antibiotics, was determined using the broth microdilution method. The ef...
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