Interleukin-8 in Tissue Injury and Inflammation

-Nathan Isaac Dibal; Sani Hyedima Garba; Tamunotonye Watson Jacks

Abstract Background: Inflammation is a vascular or tissue response that occurs as a result of infection, tissue injury or irritation. The review is aimed at describing the functions of Interleukin-8 (IL-8) and its role in tissue injury and inflammation. Methods: Articles were searched from the internet using the following search words; Inteluekin-8, IL-8 structure and functions, role of IL-8 in tissue injury, inflammation and inflammatory response, IL-8 in hepatic, nervous, cardiac and ki...

Plants- Drug Interactions Against Some Multi-drug Resistant Microorganisms Causing Urogenital Tract Infections in Cameroon

-Merveille O. Tabouguia; Denis Zofou; Jelil A. Njouendou; Marie R.T. Kouipou; Peter N. Fon, Veronique P. Beng; Jules C. Assob Nguedia

Investigational Medicinal Chemistry and Pharmacology 2018 1(1):4 Abstract Background: Multi drug resistance is an increasing phenomenon plaguing the use of antibiotics nowadays. This favors the spread of pathogenic microorganisms causing a major public health problem. Antimicrobial compounds from medicinal plants can be used synergistically to enhance the activity of standard drugs when used concurrently. The aim of this work was to evaluate the ability of extracts from Skirakiopsis ellip...

Polyphenolic extract of Paullinia pinnata leaf exhibits antidiabetic, anthyperlipidaemic and antioxidant activities in alloxan-induced diabetic rats

-Mikhail Olugbemiro Nafiu, Adijat Funmilayo Okunlade, Abeeb Abiodun Yekeen, Musa Oyewole Salawu

Abstract Background: This study evaluated the antidiabetic, antihyperlipidaemic and antioxidant effects of polyphenolic extract of Paullinia pinnata leaf (PEPPL) in alloxan-induced diabetic rats. Method: Diabetes was induced in Albino rats by intraperitoneal administration of alloxan monohydrate (120 mg/kg body weight (b. w.)). Male and female rats of average weight 150 ± 1.14 g were selected for the study. PEPPL at a dose of 25 and 50 mg/kg b. w. was administered single dose per day to a...

Cytotoxicity of Lupeol from the Stem Bark of Zanthoxylum gilletii against Multi-factorial Drug Resistant Cancer Cell Lines

-Helder Ombui Nyaboke, Martha Moraa, Leonidah Kerubo Omosa, Armelle T. Mbaveng, Nchiozem-Ngnitedem Vaderament-Alexe, Veronicah Masila, Evans Okemwa, Matthias Heydenreich, Thomas Efferth, Victor Kuete

Investigational Medicinal Chemistry and Pharmacology 2018 1(1):10. Abstract Background: Drug resistance is one of the major hurdles in the treatment of cancer. Rather than single factors, drug resistance is caused by multiple mechanisms making it even more complex. In the present study, the cytotoxicity of six compounds isolated from Zanthoxylum gilletii were screened against drug-sensitive leukemia CCRF-CEM cells. The most cytotoxic compound, lupeol (1) was further tested in a panel of n...

Hepatoprotective activities of Autranella congolensis and Sapium ellypticum against carbone tetrachloride induced liver injuries in experimental rats.

-Abdel Jelil Njouendou; Jules Clement Nguedia Assob; Merveille Octavie Tabouguia; Kofia Mbarawa; Peter Nde-Fon; Veronique Penlap Beng; Samuel Wanji; Alango Pepin Nkeng-Efouet.

Abstract Background: Liver injury remains a serious problem worldwide despite advances in drug research. In the perspective of searching for new natural agents that can prevent such abnormalities this study was designed to evaluate the in vivo anti-oxidative properties of the methanolic extracts of Autranella congolensis and Sapium ellypticum. Methods: The hepatoprotective properties of the extracts were evaluated on 9 groups of 5 Wistar rats using the CCl4 model. Animals were treated oral...

Anthelmintic resistance modifying properties of extracts of Cyperus difformis L. (Cyperiaceae)

-Francis Adu; Christian Agyare; George Henry Sam; Yaw Duah Boakye; Vivian Etsiapa Boamah.

Francis Adu1, Christian Agyare1*, George Henry Sam2, Yaw Duah Boakye1, Vivian Etsiapa Boamah1 Investigational Medicinal Chemistry and Pharmacology 2018 1(1):3 Abstract Background: Resistance by parasites to anthelmintic drugs is known to be on the increase and little attention is paid to the subject. The aim of study was to determine the anthelmintic and helminth resistance modifying activities of methanol whole plant Cyperus difformis extract against the adult Indian worm Pherethima p...

Catechin Derivatives from Parkia biglobosa Displayed Selective Cytotoxicity Towards Leukemia CCRF-CEM Cell Line and its P-Glycoprotein Expressing Subline CEM/ADR5000

-Victor Kuete; Viviane R. Sipowo Tala; Armelle T. Mbaveng; Viviane Cândida da Silva; Clenilson M. Rodrigues; Augustin E. Nkengfack; Lourdes Campaner dos Santos; Wagner Vilegas; Thomas Efferth.

Investigational Medicinal Chemistry and Pharmacology 2018; 1(1):2 Abstract Background: Cancer chemotherapy is challenged by drug resistance of malignant cells. In the present work, we evaluated the cytotoxicity of four catechin derivatives, 4’-methylepigallocatechin (1), gallocatechin (2), epigallocatechin (3), epigallocatechin-3-O-gallate (4) against nine drug sensitive and multidrug resistant (MDR) cancer cell lines. Methods: The resazurin reduction assay was used to evaluate the cyt...

Anti-staphylococcal and antibiotic-potentiating activities of seven Cameroonian edible plants against resistant phenotypes

-Hermione T. Manekeng; Armelle T. Mbaveng; Gaelle S. Nguenang; Jackson A. Seukep; Brice E. N. Wamba; Paul Nayim; Ngai R. Yinkfu; Aimé G. Fankam, Victor Kuete

Hermione T. Manekeng1, Armelle T. Mbaveng1*, Gaelle S. Nguenang1, Jackson A. Seukep1, Brice E. N. Wamba1, Paul Nayim1, Ngai R. Yinkfu1, Aimé G. Fankam1 and Victor Kuete1 Investigational Medicinal Chemistry and Pharmacology 2018 1(1):7 Abstract Background: In this study, we evaluated the anti-staphylococcal and antibiotic-potentiating activities against resistant phenotypes of seven Cameroonian dietary plants: Arachis hypogaea; Cola pachycarpa; Curcuma longa; Lycopersicon esculentum; Ma...

Antibacterial activity of four Cameroonian medicinal plants against MDR bacteria and study of mode of action

-Irene Chinda Kengne; Jean-De-Dieu Tamokou

Irene Chinda Kengne1, Jean-De-Dieu Tamokou1* Abstract Background: The increasing number of resistant bacteria to commonly used antibiotics makes the search for new active molecules a real challenge. The aim of this study is to evaluate the antibacterial activities of crude extracts and fractions from four Cameroonian medicinal plants against multi-resistant bacteria as well their mechanisms of action. Methods: The crude extracts were prepared by maceration in methanol. The fractionatio...

In vitro Evaluation of Antioxidant and Anti-sickling properties of Theobroma Cacao (Sterculiaceae) extracts from East and South regions in Cameroon

-Natacha L. Yembeau; Prosper C.N. Biapa; Bernard Chetcha; Flora L. Nguelewou; Christian F. Kengne; Prudence J.N. Nkwikeu; Phelix Bruno Telefo; Constant A. Pieme

Abstract Background: Sickle cell anaemia (SCA) is a genetic disease associated with increased mortality in Africa. It generates polymerization of haemoglobin, free radicals proliferation and antioxidants deficiencies. SCA management still needs new and safe drugs. The aim of this study is to evaluate the antioxidant and anti-sickling properties of cocoa extracts from two localities of Cameroon. Methods: T. cacao beans were collected in Bertoua and Mbalmayo They were dried, ground and then...