Abstract
Background: The Cameroonian pharmacopoeia is full of many plants used amongst population to treat various infections. Albizia adianthifolia (Schum.) is one of these plants and therefore several previous studies have reported the antibacterial activities of the crude methanol extract of the roots of this plant as well as those of some of its isolated compounds. In this study, the methanol root extract, and its isolated compound "adianthifolioside GS1" were evaluated on bact...
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Acetylcholinesterase inhibitory, anti-inflammatory and antioxidant properties of some Cameroonian medicinal plants used to treat some neurological disorders
Abstract
Background: Besides the principal hallmark of Alzheimer’s disease (AD) and Parkinson’s disease (PD) which is accumulation of mis-folding protein in the brain; cholinergic deficit, neuro-inflammation and oxidative stress are also implicated the pathogenesis of the above-mentioned diseases. In the present study, different plant parts were collected in an ethnopharmacological survey carried out in the Noun Division (West Region, Cameroon).
Methods: A total of 29 methylene chloride-m...
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Investigation of antimicrobial and antioxidant properties of extracts of the stem bark of Drypetes floribunda (Euphorbiaceae)
Abstract
Background: The use of the stem bark of Drypetes floribunda in the treatment of microbial infections is common amongst the people of Kwahu Asakraka in the Eastern Region of Ghana. However not much studies have been done to establish the scientific basis of this and to isolate the bioactive principles from the stem bark. Objectives: To assess the antimicrobial and antioxidant properties of the stem bark and to isolate some bioactive principles and investigate their antimicrobial act...
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Antiproliferative properties of labdane diterpenoids from Croton sylvaticus Hochst against drug sensitive and resistant leukemia cell lines
Abstract
Background: Cancer treatment failure is majorly attributed to the emergency of multi-drug resistance of cancer cells towards most conventional drugs used in chemotherapy hence the need for more active principles with less side effective from natural sources.
Methods: Characterization of isolated compounds was achieved using NMR spectroscopy and comparison of acquired data with literature values. The antiproliferative properties were determined using resazurin reduction assay.
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Anti-leishmanial activity of some surface compounds of Tarchonanthus camphoratus
Abstract
Background:The world health organization recognizes leishmaniasis as a major tropical disease with no effective vaccine against it. Chemotherapy, the only effective way to treat all forms of the disease, is toxic and expensive. Hence, there is need for scientists to scale up the search for new anti-leishmanial agents. The present study investigated the in vitro anti-leishmanial activity of five surface compounds of Tarchonanthus camphoratus.
Methods: The surface exudates were obt...
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Sedative, Anticonvulsant and Analgesic activities of Fresh Leaf Essential Oil of Plectranthus aegyptiacus from Southwest Nigeria in Mice
Abstract
Background: The folkloric use of Plectranthus aegyptiacus (Forssk.) C. Chr. in the Southwest Nigeria includes;pain, sensory diseases, cough and fever. This study investigated the anxiolytic, sedative, anticonvulsant and analgesic activities of the essential oil of P.aegyptiacus in mice.
Methods: The oil was extracted by hydro-distillation.5% Tween-80 (0.1 ml/10 g)was used as negative control and different standard drugs were used as positive controls depending on the model. The ...
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Protective effect of ethanolic extract and raw juice of Solanum betaceum on aluminum induced oxidative stress and associated memory deficits in rats
Abstract
Background: Oxidative stress is known to contribute to the mechanisms underpinning the pathogenesis of neurodegenerative diseases. Previous studies have identified the presence of flavonoids as the major constituents of Solanum betaceum (SB) with antioxidant activity. This work aims at investigating the protective effect of ethanolic extract and raw juice of Solanum betaceum (SB) on aluminum induced oxidative stress and associated memory deficits in Wistar rats.
Methods: Memor...
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Therapeutic Impacts of Garlic Varieties on Hyperlipidemia Induced In Male Wistar Rats
Abstract
Background: Every year, cardiovascular diseases take the lives of 17.7 million people accounting for 31% of all global deaths with atherosclerotic cardiovascular disease being the leading cause of mortality. Interestingly, hyperlipidemia is an important modifiable risk factor contributing to atherosclerosis.
Methods: Qualitative phytochemical screenings was done according to standard protocols. For hyperlipidemia protocol, animals were divided randomly into 4 groups of 6 rats eac...
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Cinnamomum zeylanicum, Dichrostachys glomerata and three other plants had anti-staphylococcal and antibiotic-modifying activity against drug-resistant phenotypes
Abstract
Background: The increase resistance of Staphylococcus aureus clinically, propels the search of novel approaches to treat staphylococcal infections. This study aims to investigate the anti-staphylococcal activity and antibiotic-modulating effects of the methanol extracts of five Cameroonian dietary plants namely Cinnamomum zeylanicum, Fagara xanthoxyloides, Imperata cylindrica, Dichrostachys glomerata, Pentadiplanara brazzeana against a panel of S. aureus strains.
Methods: The pl...
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Protective Mechanisms of Limonoids from Khaya grandifoliola against Cisplatin-Toxicity in L-02 Hepatocytes: Targeting JNK Activation and Nuclear Translocation of Nrf2
Abstract
Background: Cisplatin is one of the most effective
antineoplastic drugs, but it has undesirable side effects such as
hepatotoxicity. This study investigated in
vitro the protective activity of three limonoids known as
17-epi-methyl-6-hydroxylangolensate, 7-deacetoxy-7-oxogedunin and
deacetoxy-7R-hydroxygedunin, isolated from Khaya
grandifoliola (Meliaceae) against
cisplatin-induced hepatotoxicity and the possible mechanisms involved in this
activity.
Methods: Normal human liver...
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