Protective effect of ethanolic extract and raw juice of Solanum betaceum on aluminum induced oxidative stress and associated memory deficits in rats

-Anne P.N. Kengne; Rodrigue Tidjong; Dieudonné Kuate; Hermine T. Doungue; Prosper N.Takam; Inelle Makamwé

Abstract Background: Oxidative stress is known to contribute to the mechanisms underpinning the pathogenesis of neurodegenerative diseases. Previous studies have identified the presence of flavonoids as the major constituents of Solanum betaceum (SB) with antioxidant activity. This work aims at investigating the protective effect of ethanolic extract and raw juice of Solanum betaceum (SB) on aluminum induced oxidative stress and associated memory deficits in Wistar rats. Methods: Memor...

Therapeutic Impacts of Garlic Varieties on Hyperlipidemia Induced In Male Wistar Rats

-René Nia; Abia S. Njang; Ufuan A. Achidi; Bernard Tiencheu; Germain S. Taiwe

Abstract Background: Every year, cardiovascular diseases take the lives of 17.7 million people accounting for 31% of all global deaths with atherosclerotic cardiovascular disease being the leading cause of mortality. Interestingly, hyperlipidemia is an important modifiable risk factor contributing to atherosclerosis. Methods: Qualitative phytochemical screenings was done according to standard protocols. For hyperlipidemia protocol, animals were divided randomly into 4 groups of 6 rats eac...

Cinnamomum zeylanicum, Dichrostachys glomerata and three other plants had anti-staphylococcal and antibiotic-modifying activity against drug-resistant phenotypes

-Garandi Badawe, Aimé G. Fankam, Armelle T. Mbaveng, Brice E. N. Wamba, Paul Nayim, Victor Kuete

Abstract Background: The increase resistance of Staphylococcus aureus clinically, propels the search of novel approaches to treat staphylococcal infections. This study aims to investigate the anti-staphylococcal activity and antibiotic-modulating effects of the methanol extracts of five Cameroonian dietary plants namely Cinnamomum zeylanicum, Fagara xanthoxyloides, Imperata cylindrica, Dichrostachys glomerata, Pentadiplanara brazzeana against a panel of S. aureus strains. Methods: The pl...

Protective Mechanisms of Limonoids from Khaya grandifoliola against Cisplatin-Toxicity in L-02 Hepatocytes: Targeting JNK Activation and Nuclear Translocation of Nrf2

-Arnaud Fondjo Kouam, Frédéric Nico Njayou, Fei Yuan, Babayemi Olawale Oladejo, Pierre Mkounga, Fuhang Song, Paul Fewou Moundipa

Abstract Background: Cisplatin is one of the most effective antineoplastic drugs, but it has undesirable side effects such as hepatotoxicity. This study investigated in vitro the protective activity of three limonoids known as 17-epi-methyl-6-hydroxylangolensate, 7-deacetoxy-7-oxogedunin and deacetoxy-7R-hydroxygedunin, isolated from Khaya grandifoliola (Meliaceae) against cisplatin-induced hepatotoxicity and the possible mechanisms involved in this activity. Methods: Normal human liver...

CYP450–mediated metabolites of aqueous leaves extract of Moringa oleifera inhibits absorption of chloroquine in Plasmodium yoeli yoeli infection

-Segun Solomon Ogundapo; Olajoju Temidayo Soniran; Joseph Bagi Suleiman; Kerian Chigozie Ngobidi; Nwogo Ajuka Obasi; Victor Uzochukwu Olugbue; Oswald Obinna Chukwunwike; Idowu David Olatunji

Abstract Background: This study tested an in vivo model designed to evaluate the potential of HDI of chloroquine and aqueous leaf extract of Moringa oleifera to overcome multi-drug resistant Plasmodium yoeli yoeli infection in albino mice. Methods: Using Rane’s test, 40 male albino mice were randomized into 10 groups of four mice each. Nine groups inoculated with multidrug-resistant strains of Plasmodium yoeli yoeli were treated with water, 150 mg/kg of Moleifera oleifera aqueous leaf extract, 1...

Potentiation of chloroquine by antiplasmodial fraction of moringa oleifera leaves in drug resistant Plasmodium berghei infection

-Solomon S. Ogundapo; Lawrence U.S. Ezeanyika; Pete N. Uzoegwu; Olajoju T. Soniran.

Abstract Background:This study assessed changes in blood chemistry associated with co-administration of chloroquine with antiplasmodial fraction of crude methanol extract of Moringa oleifera leaves. Methods: Partial phytochemical profiling of antiplasmodial extract was done using standard methods. Using Rane’s test, 60 male albino mice were randomized into 10 groups of six mice each. Nine groups were inoculated with quinine resistant strains of Plasmodium berghei and treated with tween 80,10mg/k...