Mechanisms of action of roots crude extract and adianthifolioside GS1 from Albizia adianthifolia (Fabaceae) against MDR Gram-negative enteric bacteria

-Cedric F. Tchinda; Igor K. Voukeng; Veronique P. Beng; Victor Kuete

Abstract Background: The Cameroonian pharmacopoeia is full of many plants used amongst population to treat various infections. Albizia adianthifolia (Schum.) is one of these plants and therefore several previous studies have reported the antibacterial activities of the crude methanol extract of the roots of this plant as well as those of some of its isolated compounds. In this study, the methanol root extract, and its isolated compound "adianthifolioside GS1" were evaluated on bact...

Acetylcholinesterase inhibitory, anti-inflammatory and antioxidant properties of some Cameroonian medicinal plants used to treat some neurological disorders

-Ngoungoure VLN; Mfotie Njoya E; Ngamli Fewou S; Ella AF; McGaw LJ; Moundipa PF

Abstract Background: Besides the principal hallmark of Alzheimer’s disease (AD) and Parkinson’s disease (PD) which is accumulation of mis-folding protein in the brain; cholinergic deficit, neuro-inflammation and oxidative stress are also implicated the pathogenesis of the above-mentioned diseases. In the present study, different plant parts were collected in an ethnopharmacological survey carried out in the Noun Division (West Region, Cameroon). Methods: A total of 29 methylene chloride-m...

Investigation of antimicrobial and antioxidant properties of extracts of the stem bark of Drypetes floribunda (Euphorbiaceae)

-Alex Boateng; Joseph K. Adu; Michael K. Baah

Abstract Background: The use of the stem bark of Drypetes floribunda in the treatment of microbial infections is common amongst the people of Kwahu Asakraka in the Eastern Region of Ghana. However not much studies have been done to establish the scientific basis of this and to isolate the bioactive principles from the stem bark. Objectives: To assess the antimicrobial and antioxidant properties of the stem bark and to isolate some bioactive principles and investigate their antimicrobial act...

Antiproliferative properties of labdane diterpenoids from Croton sylvaticus Hochst against drug sensitive and resistant leukemia cell lines

-Kefah Nyatuka Okerio, Evans Okemwa Kenanda, Leonidah Kerubo Omosa

Abstract Background: Cancer treatment failure is majorly attributed to the emergency of multi-drug resistance of cancer cells towards most conventional drugs used in chemotherapy hence the need for more active principles with less side effective from natural sources. Methods: Characterization of isolated compounds was achieved using NMR spectroscopy and comparison of acquired data with literature values. The antiproliferative properties were determined using resazurin reduction assay. ...

Anti-leishmanial activity of some surface compounds of Tarchonanthus camphoratus

-Okemwa Evans Kenanda; Leonidah Kerubo Omosa

Abstract Background:The world health organization recognizes leishmaniasis as a major tropical disease with no effective vaccine against it. Chemotherapy, the only effective way to treat all forms of the disease, is toxic and expensive. Hence, there is need for scientists to scale up the search for new anti-leishmanial agents. The present study investigated the in vitro anti-leishmanial activity of five surface compounds of Tarchonanthus camphoratus. Methods: The surface exudates were obt...

Sedative, Anticonvulsant and Analgesic activities of Fresh Leaf Essential Oil of Plectranthus aegyptiacus from Southwest Nigeria in Mice

-Enimeya Dressman Akuegbe, Idris Ajayi Oyemitan, Idowu Julius Olawuni, Adebola Omowumi Oyedeji

Abstract Background: The folkloric use of Plectranthus aegyptiacus (Forssk.) C. Chr. in the Southwest Nigeria includes;pain, sensory diseases, cough and fever. This study investigated the anxiolytic, sedative, anticonvulsant and analgesic activities of the essential oil of P.aegyptiacus in mice. Methods: The oil was extracted by hydro-distillation.5% Tween-80 (0.1 ml/10 g)was used as negative control and different standard drugs were used as positive controls depending on the model. The ...