Antibacterial, antioxydant and antidiarrheal properties of Tristemma hirtum P. beauv.

-Jaurès A. K. Noumedem;, Doriane E. Djeussi; Gerald Ngo Teke; Jean D. Tamokou; Jules R. Kuiate

Abstract Background: The aim of this study was to investigate the antibacterial, radical-scavenging and antidiarrheal properties of Tristemma hirtum. Methods: The methanol extract of Tristemma hirtum was prepared by successive fractionation in hexane and ethyl acetate solvents. The phytochemical composition of crude extract and fractions was studied using standard methods. Their antimicrobial activities were evaluated against Gram-negative and Gram-positive species of pathogenic bacteria ...

Table of Contents _ Volume3, issue 1; July 31, 2020

Volume3, issue 1; July 31, 2020 (Available at: https://www.investchempharm.com/volume/volume3/issue-1/) https://dx.doi.org/10.31183/imcp.2020.v3i1 Research Article 1- Antipsychotic and anticonvulsant effects of crude aqueous leaf extract of Vitex doniana Sweet (Verbenaceae) In mice Authors: Joshua Oloruntobi Imoru, Idris Ajayi Oyemitan and Atanda Moses Akanmu. Investigational Medicinal Chemistry and Pharmacology 2020 3(1):35. doi: https://dx.doi.org/10.31183/imcp.2020.00034 ...

Antimicrobial and antioxidant activities of isolated compounds from the root bark of Croton pseudopulchellus (Euphorbiaceae)

-Jöel S.N. Tatsimo; Jean D.D. Tamokou; Léopold Havyarimana; Irene C. Kengne; Steve E. Ekom; Alain M. Lannang; Norbert Sewald.

Abstract Background: Despite the significant progress made in microbiology and the control of microorganisms, sporadic incidents of epidemics due to drug resistant microorganisms pose an enormous threat to public health. Hence, search for new antimicrobial is very important to overcome microbial resistance and emerging pathogenic bacteria and fungi. In this study, we designed to describe the isolation, structure elucidation, antimicrobial and antioxidant activities of components from the roo...

Anti-amnesic effect of ethanol stem bark extract and fractions of Milicia excelsa (Moraceae) in mice

-Lateef A. Akinpelu; Muritala A. Adebayo; Oyeronke M. Aiyelero; Rotimi T. Alamojin; Chidinma J. Mbara; Isiaka A. Ogunwande.

Abstract Background: Amnesia is associated with normal aging and neuropsychiatric disorders with no known medical cure. Medicinal plants used in traditional medicines to combat neuropsychiatric disorders may be a veritable vehicle towards providing the appropriate drug candidate(s). Methods: Hence, this study assessed the anti-amnesic potential of Milicia excelsa stem bark upon its widespread use in traditional medicine for treating mental illnesses. The anti-amnesic potentials of ethanol...

Methanol Extracts from Manilkara zapota with Moderate Antibacterial Activity Displayed Strong Antibiotic-Modulating Effects against Multidrug-Resistant Phenotypes

-Franklin C. M. Ngongang; Aimé G. Fankam; Armelle T. Mbaveng; Brice E. N. Wamba; Paul Nayim; Veronique P. Beng; Victor Kuete.

Abstract Background: The emergence and persistence of multidrug-resistant (MDR) bacteria appears today as a serious threat of growing concern to human health. The aim of this present study was to investigate the antibacterial and antibiotic-modulating activity of the methanol extracts of Manilkara zapota (L.) P. Royen (Sapotaceae) against pathogenic strains belonging to Gram-positive bacterium, Staphylococcus aureus, and Gram-negative bacteria. Methods: The antibacterial activity as well ...

Aqueous extracts of Desmodium adscendens (Fabaceae) possess in vitro antioxidant properties and protect hepatocytes from Carbone tetrachloride-induced injury and Hepatitis C Virus infection

-Pascal D.D. Chuisseu; Borris R.T Galani; Nelly C.K. Younang; Arnaud F. Kouam; Brice F.N. Simo; Angèle N. Tchana; Karin Seron; Jean Dubuisson; Gisa Tiegs; Jonas Kouamouo; Paul F. Moundipa.

Abstract Background: Desmodium adscendens (DA) is an herbaceous plant found in Africa and South America and used in traditional medicine against liver-related diseases. In the present study, the aqueous decoctions from DA were tested for its antioxidant and hepato-(protective and curative) properties on CCl4-induced acute injury on primary culture rats’ hepatocytes. We also investigated its inhibitory effects on hepatitis C virus (HCV) using genotype 1b subgenomic replicon systems and cell-c...

Antibacterial potential and mechanism of action of botanicals and phytochemicals from Stachytarpheta cayennensis (Verbenaceae) against Gram-negative multidrug-resistant phenotypes expressing efflux pumps

-Laetitia M. Youmbi; Brice C.K. Atontsa; Simplice B. Tankeo, Brice E. N. Wamba; Paul Nayim; Blaise K. Nganou; Gabin T.M. Bitchagno; Ingrid K. Simo; James D.S. Mpetga; Veronique B. Penlap; Victor Kuete

Abstract Background: The effectiveness of antibiotics in the fight against bacterial infections motivated their massive use which resulted in the appearance of resistant bacteria. This phenomenon is nowadays in constant evolution and represents a major problem of public health. In this respect, the search for new molecules for fighting against bacterial resistance is essential. This work was committed to studying the in vitro antibacterial activity of the ethanol crude extract, fra...

Antipsychotic and anticonvulsant effects of crude aqueous leaf extract of Vitex doniana Sweet (Verbenaceae) In mice

-Joshua Oloruntobi Imoru, Idris Ajayi Oyemitan and Atanda Moses Akanmu

Abstract Background: This work evaluated the antipsychotic and anticonvulsant effects of crude aqueous leaf extract of Vitex doniana in mice. This was to validate the use of V. doniana in the treatment of mental disorders and epilepsy in folkloric medicine. Methods: Antipsychotic effect of V. doniana was evaluated using the animal models of psychosis: swimming-induced grooming, ketamine-induced hyperlocomotion and apomorphine-induced climbing tests. Anticonvulsant effect was evaluated usi...